{"created":"2023-05-15T15:12:27.665025+00:00","id":238,"links":{},"metadata":{"_buckets":{"deposit":"f77fa564-e7b6-4c07-9f8c-301e86ce99b7"},"_deposit":{"created_by":16,"id":"238","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"238"},"status":"published"},"_oai":{"id":"oai:ompu.repo.nii.ac.jp:00000238","sets":["111:48:64"]},"author_link":["439","440","441","442","443"],"control_number":"238","item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"33","bibliographicPageStart":"27","bibliographicVolumeNumber":"64","bibliographic_titles":[{"bibliographic_title":"Bulletin of the Osaka Medical College","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Endothelial basement membrane (BM) is a sheet-like extracellular matrix lining the abluminal surface of endothelium and plays critical roles in vascular function. During angiogenesis, the BM is digested locally when endothelial \ncells sprout, and reassembled when a new branch is formed. However, the detailed changes of BMs in developing blood \nvessels remain to be clarified. We used neonatal mouse retina as a model of angiogenesis and observed BM structure \nand composition. Whole-mount immunohistochemistry revealed co-localization of major BM proteins including \nlaminins, type IV collagen, nidogen, and perlecan around the endothelial tip cells, which suggested the presence of \nendothelial BM even at the tip of growing vessels. The BMs of the tip cells contained only laminin α4 as a major \nlaminin subunit, while that of “root” vessels contained both laminins α4 and α5, indicating that BM components change \nalong with vessel maturation. MMP-9 immunoreactivities were found in association with endothelial BMs, suggesting \nthat MMP-9 plays a role in remodeling of endothelial BM in developing retinal vascular network. These observations \nsuggested that the BM is a constitutive structure for the vascular development and its components are regulated by \nvascular maturation and environmental factors.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10002_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.57371/00000223","subitem_identifier_reg_type":"JaLC"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Osaka Medical College","subitem_publisher_language":"en"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0916-2844","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"IIDA, Tomoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"439","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"FUTAKI, Sugiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"440","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SHIBATA, Masa-Aki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"441","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"OTSUKI, Yoshinori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"442","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KONDO1, Yoichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"443","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-10-22"}],"displaytype":"detail","filename":"64_04_.pdf","filesize":[{"value":"153.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"64_04_","url":"https://ompu.repo.nii.ac.jp/record/238/files/64_04_.pdf"},"version_id":"35b950a3-8566-4ef1-ac32-3dc9e61a3bd0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Differential Localization of Laminin Subunits and MMP-9 in Mouse Retinal Angiogenesis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Differential Localization of Laminin Subunits and MMP-9 in Mouse Retinal Angiogenesis","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"16","path":["64"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-10-25"},"publish_date":"2021-10-25","publish_status":"0","recid":"238","relation_version_is_last":true,"title":["Differential Localization of Laminin Subunits and MMP-9 in Mouse Retinal Angiogenesis"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-11-10T06:11:00.626460+00:00"}