@article{oai:ompu.repo.nii.ac.jp:00000281,
 author = {SHIMIZU, Tetsunosuke and TANIGUCHI, Kohei and ASAKUMA,  Mitsuhiro and TOMIOKA, Atsushi and KAGOTA, Shuji and KOMEDA, Koji and LEE,  Sang-Woong and HIROKAWA, Fumitoshi and UCHIYAMA, Kazuhisa},
 issue = {1-2},
 journal = {Bulletin of Osaka Medical and Pharmaceutical University},
 month = {Dec},
 note = {Pancreatic cancer is a leading cause of cancer-related deaths. Although advances in chemotherapy and radiotherapy have improved patient outcomes, pancreatic cancer remains a refractory disease. Herein, we describe a patient with 
pancreatic cancer who underwent an effective multidisciplinary treatment comprising heavy particle radiotherapy and 
hyperthermia. A 64-year-old woman underwent distal pancreatectomy for pancreatic cancer; however, a single liver 
metastasis was discovered 12 months after surgery. Heavy particle radiotherapy and oral tegafur/gimeracil/oteracil 
were administered to treat the metastasis. Thereafter, the patient underwent laparoscopic lateral segmentectomy of the 
liver. However, 12 months after hepatectomy, peritoneal dissemination with elevated serum carbohydrate antigen 19-9 levels was detected. The patient received combination therapy with gemcitabine and nanoparticle albumin-bound 
paclitaxel and subsequently underwent hyperthermia therapy with low-dose S-1 administration. While serum carbohydrate antigen 19-9 levels decreased more than expected over the first 9 months of hyperthermia therapy, the patient 
died the following month. Overall, the patient survived for 4 years after liver metastasis was detected and 3 years 
post-peritoneal dissemination. In an era where novel therapeutic strategies are required for treating aggressive malignancies, our report illustrates the potential effectiveness of multidisciplinary treatments in patients with unresectable 
pancreatic cance},
 pages = {31--35},
 title = {Multidisciplinary Treatment Comprising Heavy Particle Radiotherapy  and Hyperthermia is Effective Against Liver Metastasis Arising from  Pancreatic Cancer: A Case Report},
 volume = {67},
 year = {2021}
}