{"created":"2023-05-15T15:12:29.566820+00:00","id":321,"links":{},"metadata":{"_buckets":{"deposit":"9ec0ab41-8ba0-4cd1-b777-973e686ad8d4"},"_deposit":{"created_by":16,"id":"321","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"321"},"status":"published"},"_oai":{"id":"oai:ompu.repo.nii.ac.jp:00000321","sets":["83:116"]},"author_link":["606","607","608","609","610","611"],"control_number":"321","item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"37","bibliographicPageStart":"29","bibliographicVolumeNumber":"68","bibliographic_titles":[{"bibliographic_title":"Bulletin of Osaka Medical and Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Type 1 diabetes (T1D) is characterized by immune-related pancreatic β-cell destruction. The CD300e antibody level transiently increases during the acute phase of fulminant T1D (FT1D). Here, we investigated the contribution of CD300e to T1D development. Monocytes were obtained from 20 patients with FT1D, 25 with acute onset T1D (AT1D), 14 with type 2 diabetes (T2D), and 17 healthy controls (HCs). Additionally, peripheral blood mononuclear cells (PBMCs) were obtained from 8 patients with FT1D, 12 with AT1D, 11 with T2D, and 9 HCs. Using flow cytometry, we analyzed CD300e expression in monocytes and myeloid dendritic cells in PBMCs. Tumor necrosis factor (TNF)-α was measured after the stimulation of monocytes with 3.3 ng/µL sphingomyelin (SM), a CD300e ligand. The percentage of CD300e-positive cells in the monocytes of patients with AT1D was higher than that in those of HCs (p = 0.006). \nThe percentage of CD300e-positive cells was higher in female participants than in male participants, and was negatively correlated with the estimated glomerular filtration rate and age (sex p = 0.023, eGFR p = 0.028, age p = 0.023). \nThere was no difference in SM-stimulated TNF-α production by monocytes among diabetic subtypes. We showed differences in CD300e expression in human monocytes with diabetes type, sex, age, and renal function. These results provide information on the physiological features of CD300e and insights into the role of CD300e in AT1D pathogenesis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Osaka Medical and Pharmaceutical University","subitem_publisher_language":"en"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2436-4673","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"MORIMOTO, Takako","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"606","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HIRAO, Mayumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"607","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SANO, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"608","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TERASAKI, Jungo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"609","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HANAFUSA, Toshiaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"610","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"IMAGAWA, Akihisa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"611","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-09-15"}],"displaytype":"detail","filename":"bullompu68_1-2_4 MORIMOTO.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"url":"https://ompu.repo.nii.ac.jp/record/321/files/bullompu68_1-2_4 MORIMOTO.pdf"},"version_id":"2e37baef-0cf9-47ac-af7d-fe56559b8990"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"High Monocyte CD300e Expression in Patients with  Acute Onset Type 1 Diabetes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"High Monocyte CD300e Expression in Patients with  Acute Onset Type 1 Diabetes","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"16","path":["116"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-03"},"publish_date":"2023-03-03","publish_status":"0","recid":"321","relation_version_is_last":true,"title":["High Monocyte CD300e Expression in Patients with  Acute Onset Type 1 Diabetes"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2024-04-10T07:48:11.706056+00:00"}