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Effects of Temporary Blood Administration on Dysoxia and Survival in a Rat Uncontrolled Hemorrhagic Shock Model
https://ompu.repo.nii.ac.jp/records/276
https://ompu.repo.nii.ac.jp/records/2765eee06be-ac85-4d36-818e-dfa7eddbcb21
名前 / ファイル | ライセンス | アクション |
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bullompu67_1-2_1 SAKAUE.pdf (427 KB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2022-02-08 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Effects of Temporary Blood Administration on Dysoxia and Survival in a Rat Uncontrolled Hemorrhagic Shock Model | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
SAKAUE, Masahide
× SAKAUE, Masahide× TAKASU, Akira |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective: To test whether temporary blood administration improves dysoxia and thereby prolong survival in an ongoing uncontrolled hemorrhagic shock model. Methods: Light anesthesia was induced with sevoflurane in 18 rats, and spontaneous breathing was maintained. Uncontrolled hemorrhagic shock (UHS) was induced by withdrawal of blood at 2.5 mL / 100 g over a 15-min period, followed by 75 % tail amputation. At 10 min after tail cutting, rats were randomized into three groups (n = 6 each) and received the following resuscitation regimen for 20 min: Group 1 (9 mL shed blood) vs. Group 2 (a mixture of 4.5 mL NS solution and 4.5 mL shed blood) vs. Group 3 (9 mL NS solution). The rats were then monitored for oxygen metabolisms and survival. Results: The regimen of Group 1 vs. Group 3 prompted a surge in blood pressure and improved oxygen metabolic indices. Four rats in Group 1, three rats in Group 2, and none in Group 3 survived up to 180 min (p = 0.052; Group 1 vs. Group 3). Additional blood loss from the tail stump did not differ significantly among the groups. Conclusions: In a model of UHS in rats, a temporary resuscitation regimen of whole blood administration compared with NS solution improved tissue dysoxia and possibly survival. |
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言語 | en | |||||
書誌情報 |
en : Bulletin of Osaka Medical and Pharmaceutical University 巻 67, 号 1-2, p. 1-7, 発行日 2021-12 |
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出版者 | ||||||
言語 | en | |||||
出版者 | Osaka Medical and Pharmaceutical University | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2436-4673 |